Ionis Pharmaceuticals: Promising Growth From Tryngolza Approval
Learn about Ionis Pharmaceuticals' innovative RNA-targeted therapy and their potential for significant revenue growth. Read ...
生物通5 天
表观修饰改变长链非编码RNA结构进而调控气孔运动的分子机制
在昼夜周期中，气孔有节奏的张开与闭合维持着植物正常生长发育，一氧化氮（NO）信号在调节气孔运动中发挥着重要作用。拟南芥硝酸还原酶基因NIA1?是NO生物合成的关键基因；在保卫细胞中，NIA1合成NO维持气孔正常闭合。团队研究发现，NIA1基因3’UT ...
Nature14 年
Antisense agent reduces LDL–cholesterol levels in high-risk patients
Mipomersen — which is being developed by Genzyme and Isis Pharmaceuticals — is a synthetic antisense oligonucleotide that targets messenger RNA encoding apolipoprotein B100 (APOB100).
腾讯网9 天
直播预告 | ASO在功能基因组研究中的应用进展线上研讨会
近年来，小核酸药物因特异性强、设计简便、研发周期短、靶点丰富等优点，成为当前生物医药领域研究的热点。小核酸药物专指靶向作用于RNA或蛋白质的一类寡核苷酸分子，包括ASO、siRNA、aptamer、sgRNA、miRNA等，其中ASO作为小核酸药物领 ...
RNA fragment is key regulator of gene expression and potential therapeutic target in cancer ...
A novel study from Korea uncovers the process of synthesis and pivotal role of the transfer RNA-derived fragment, ...
pharmaphorum2 年
AZ chases after PCSK9 rivals with antisense drug
AstraZeneca's take on the PCSK9 inhibitor – an antisense drug licensed from Ionis ... competition – notably Novartis' small interfering RNA (siRNA) therapy Leqvio (inclisiran), which only ...
Michigan Technological University2 个月
Yinan Yuan
I am interested in deciphering the functional role of noncoding RNA (ncRNA) in gene regulation network governing forest tree growth and development. One significant class of such ncRNA is natural ...