Regulation of transcription in eukaryotes ... difference between eukaryotic and prokaryotic DNA is the formation of chromatin in eukaryotes. Chromatin results in the different transcriptional ...

This represents a conceptual breakthrough.Not only does it offer targets for therapy for several diseases, but we are adding ...

A new study led by Prof. Yosef Buganim from the Hebrew University of Jerusalem and Dr. Abdenour Soufi from the University of ...

Caltech researchers have developed a new method to map the positions of hundreds of DNA-associated proteins within cell ...

When genes are coiled and compacted into chromatin, they're no longer accessible to transcription factors. So how does the cell know where to uncoil in a process called chromatin remodeling?

Prof. Buganim highlighted the potential impact of the findings: “By uncovering how transcription factors interact with chromatin architecture, we can better understand gene regulation and cellular ...

The proper folding of the chromatin structure plays a crucial role in the regulation of genomic DNA functions, its disruption leading to various diseases. Therefore, understanding the chromatin ...

Now, a new research project funded by the National Institutes of Health and led by a malaria expert at the University of ...

Chromatin is a combination of DNA and proteins that makes up the chromosomes in the cells of humans and other higher ...

One key discovery was the influence of chromatin topology, which refers to the folding and looping of DNA within the nucleus. These structures guide TFs along DNA pathways or concentrate them at ...

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on ...

Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and ...