It seems imagination is the only limit to AI-based protein design. But there's room for even more progress in 2025.

"We found more than 600 new effector proteins in 14,000 genes," said Juline Poirson, first author on the study and visiting scientist at U of T's Donnelly Centre for Cellular and Biomolecular Research ...

The capacity of bacteria to spread disease across the plant kingdom may be much more widespread than previously suspected, ...

They also consist of a DNA-cleaving subunit of a restriction enzyme and a sequence recognition component known as the TAL effector. TAL effector proteins are usually used by bacteria to activate genes ...

They also noted that the hinge could be used as a sensor to detect the effector. They then used the AI design to build a real-world protein using their hinge-like proteins and their newly ...

In this GTP-bound, active, state, Ras binds with high affinity to a set of cytoplasmic target or ‘effector’ proteins that initiate distinct intracellular signalling cascades. The Raf kinases ...

Considering the wide variety of cellular processes that are affected during Salmonella infection, one would expect many more effector–host protein interactions to occur than have been identified.

The novel link between nutrition and cell identity offers a new explanation for exhausted T cell identity and in turn, offers ...

Researchers have identified the protein MYO1F as a key regulator of T-cell metabolism, with implications for immune responses ...