该研究发现，从醋酸到柠檬酸的营养转换在T细胞命运决定中发挥着关键作用，这一营养转换将T细胞从活跃的效应细胞状态转变为耗竭细胞状态。这一发现强调了代谢变化如何影响T细胞的特性，并为维持 免疫 功能的干预开辟了途径。

A research team led by Prof. Wang Haoyi from the Institute of Zoology (IOZ) of the Chinese Academy of Sciences has developed ...

该研究建立了用于高通量药物筛选的 CAR-T 细胞体外耗竭模型，发现已获得 FDA 批准的小分子药物米替福新（miltefosine）通过改善糖酵解和氧化磷酸化能力来恢复耗竭T细胞受损的抗肿瘤功能。这项研究结果揭示了米替福新作为肿瘤 免疫 ...

known as a T cell, becomes exhausted, according to a new study that points the way for important new lines of investigation. ME/CFS affects an estimated 3 million people in the United States and ...

known as a T cell, becomes exhausted, according to a new study that points the way for important new lines of investigation. The study's authors knew the immune system was dysregulated in patients ...

Chronic fatigue syndrome creates conditions where pathogen-killing immune T cells become exhausted, according to a new study. Chronic fatigue syndrome creates conditions where pathogen-killing ...

相关研究结果于2024年11月8日在线发表在Nature Immunology期刊上，论文标题为“Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism”。

The novel link between nutrition and cell identity offers a new explanation for exhausted T cell identity and in turn, offers ...

Scientists have discovered that our specialized immune cells, called T cells, are what they eat -- their switch from functional to 'exhausted' depends on the switch from metabolizing acetate to ...

ITHACA, N.Y. – Chronic fatigue syndrome creates conditions where pathogen-killing immune T cells become exhausted, according to a new Cornell University study. The study’s authors knew the ...

Human single cell RNA-sequencing reveals a targetable CD8 + exhausted T cell population that maintains mouse low-grade glioma growth With the emergence of immune checkpoint inhibitor therapies for ...