Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism ... but it gradually compromises macrophage function, driving the cells to stress, inflammation and ...

The peripheral endoplasmic reticulum (ER) forms a continuous ... how the unique structure of the ER arises and supports its function is critical to developing a mechanistic understanding of ...

A central protein homeostasis hub in a eukaryotic cell is the endoplasmic reticulum, which is the gateway for protein secretion. We aim to define molecular functions of cellular factors that ...

Our research group is investigating the signalling and biological functions of GDNF neurotrophic family ligands and endoplasmic reticulum located CDNF/MANF protein families, both within and outside of ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

A novel reporter protein has been developed to enable the investigation of protein biogenesis in the ER and its disruption in disease.

The study was carried out as part of the “SCALE - Subcellular Architecture of Life" cluster initiative. The endoplasmic reticulum functions as a reservoir for calcium and carbohydrates and also serves ...

It's a core function, but little studied in the setting of cancer immunology, especially when compared to other organelles like the mitochondria or endoplasmic reticulum. "So we were interested in ...