Breast cancer cells exhibit organotropism during metastasis, showing preferential homing to certain organs such as bone, lung, liver, and brain. One potential explanation for this organotropic ...

Scientists identified early genetic mutations in healthy women’s breast cells that may lead to breast cancer, particularly in ...

These cells are known as aneuploid cells, and have an abnormal number of chromosomes. They're common in invasive breast ...

More information: Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and non-carriers harbor common breast cancer copy number alterations, Nature Genetics (2024). DOI: 10.1038 ...

The formation of blood vessels is a complex process involving the interplay of proteins and mechanical forces. In two studies ...

City of Hope® Research Spotlight offers a glimpse at groundbreaking scientific and clinical discoveries advancing lifesaving ...

By analyzing single cells from breast tissue, the study identified patterns of CNAs in luminal cells, offering insights into the early genetic changes that occur before visible signs of cancer and ...

Researchers at the University of British Columbia (UBC), BC Cancer, Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early genetic origins of ...

The luminal cells express abundant CK8, CK18, AR, Nkx3.1, PSA, and PSAP; and lack nuclear p63, CK5, CK14, and most integrins. The apoptosis regulator BCL-2 is highly expressed in basal cells and ...

Researchers have uncovered new mechanisms in blood vessel formation, showing how cells interact during lumen formation and ...