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生物通
3 天
Molecular Cell∣王嘉东/王维斌团队揭示清除复制叉特异性RNA克服肿瘤 ...
随后研究团队研究发现抑制RF-RDs会导致复制叉新生DNA的降解,并显著增加DNA末端切割和DNA断裂的发生。进一步体外生化实验和细胞实验表明,RF-RDs能够抑制核酸酶DNA2的核酸酶活性,从而减缓DNA2对复制叉的降解。研究团队进一步通过全基因组 ...
生物通
4 天
生命科学学院宋艳课题组揭示有丝分裂书签维持神经干细胞命运记忆 ...
2024年12月10日,北京大学生命科学学院宋艳课题组在国际知名学术期刊Molecular Cell上在线发表了题为“TBP bookmarks and preserves neural stem cell fate memory by ...
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