The biological effects of p53 pathway variants at the molecular level in primary cells or in vivo still need to be determined. The design of genetically engineered mice using knock-in and knockout ...

Dissection of the signalling pathways mediating apoptosis — controlled cell death ... TNF, NF-κB and p53. This interest in part stems from the substantial potential to therapeutically ...

Selective modulation of the apoptotic machinery has been the goal of oncology developers for more than two decades. The field continues to face special challenges. Many of the targets are ...

Westlake University in China and the California Institute of Technology have designed a protein-based system inside living ...