γδ T cells: origin and fate, subsets, diseases and immunotherapy
2023年11月22日 · This review aims to thoroughly examine γδ T cell immunology and its role in diseases. Initially, we elucidate functional differences between γδ T cells and their αβ T cell counterparts.
Cancer immunotherapy by γδ T cells | Science - AAAS
γδ T cells are a unique population of immune cells that can recognize and kill tumors. They comprise an evolutionarily conserved T cell lineage that holds promise for next-generation immunotherapies aimed at reaching more diverse patient …
Function of γδ T cells in tumor immunology and their ... - Nature
2021年3月12日 · Because of their broad antigen specificity and NK-like cytotoxicity, γδ T-cell importance in tumor immunology has been emphasized. However, some γδ T-cell subsets, especially those expressing...
Key Features of Gamma-Delta T-Cell Subsets in Human Diseases …
In this review, we focus on the main characteristics of human γδ T-cell subsets in diseases and the key mechanisms that could be explored to target these cells. Keywords: human gamma-delta T cell, cytotoxicity, cytokine, NK receptor, antigen presentation, cancer, infection, autoimmunity.
γδ T cells in tissue physiology and surveillance - Nature
2020年10月14日 · γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By rapidly...
Gamma Delta (γδ) T Cells | British Society for Immunology
Gamma delta (γδ) T cells are the prototype of ‘unconventional’ T cells and represent a relatively small subset of T cells in peripheral blood. They are defined by expression of heterodimeric T-cell receptors (TCRs) composed of γ and δ chains.
γδ T cells: origin and fate, subsets, diseases and immunotherapy
2023年11月23日 · The γδ T cells account for approximately 1–5% of total T cells in peripheral blood but much higher proportions are present in various human tissues such as the intestine (nearly 40% 211) and skin (10–30% 173,183,212,213). γδ T cells represent a unique subset of lymphoid cells that exhibit characteristics of both innate and adaptive ...
γδ T cells: origin and fate, subsets, diseases and immunotherapy
2023年11月22日 · Initially, we elucidate functional differences between γδ T cells and their αβ T cell counterparts. We also provide an overview of major milestones in γδ T cell research since their discovery in 1984.
γδ T cells: Major advances in basic and clinical research in tumor ...
2024年1月5日 · γδ T cells are a kind of innate immune T cell. They have not attracted sufficient attention because they account for only a small proportion of all immune cells, and many basic factors related to these cells remain unclear.
Human γδ T-Cells: From Surface Receptors to the Therapy of High …
2018年5月6日 · γδ T-cells straddle the innate and adaptive arms of the immune system and are involved in response to pathogens [e.g., mycobacteria; cytomegalovirus (CMV)] and tumors. Similar to αβ T-cells, γδ T-cells develop in the thymus, but express a rearranged T-cell receptor (TCR) consisting of a TCR-γ and a TCR-δ chain (1).
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