More from Cancer Cell - Cell Press
Cancer Cell provides a high-profile forum to promote major advances in cancer research and oncology. The primary criterion for considering manuscripts is whether the studies provide major advances into answering important questions relevant to naturally occurring cancers.
New articles: Cancer Cell
2024年12月12日 · Here, we discuss the latest work on circulating tumor DNA and circulating tumor cells with respect to clinical applications, including cancer screening, early detection of relapse, real-time monitoring of therapeutic efficacy, and detection of therapeutic targets and resistance mechanisms.
Issue: Cancer Cell
2024年12月9日 · Aggressive features of hepatocellular carcinoma (HCC) are highly related to liver tumor-initiating cells (TICs), which are heterogeneous and plastic. In this issue of Cancer Cell, Yang et al. reveal the ability of CD49f-high TICs in shaping the tumor immunosuppressive microenvironment in HCC.
Mammalian SWI/SNF chromatin remodeling complexes promote …
2023年8月3日 · In this study, de Miguel et al. find that mammalian SWI/SNF chromatin-remodeling complexes promote osimertinib resistance in EGFR-mutant lung cancer model systems via changes in chromatin accessibility, which underlie resistance-associated gene expression and cancer cell proliferation.
Interactions between cancer cells and immune cells drive ... - Cell …
The mesenchymal subtype of glioblastoma is thought to be determined by both cancer cell-intrinsic alterations and extrinsic cellular interactions, but remains poorly understood. Here, we dissect glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional ...
A distinct stimulatory cDC1 subpopulation amplifies CD8 - Cell Press
2023年7月13日 · Our findings reveal an intratumoral phase of the anti-cancer T cell response orchestrated by tumor-residing cDC1 that determines protective versus ineffective immunity and could be exploited for cancer therapy.
Mammalian SWI/SNF complex activity regulates POU2F3 and
2024年7月18日 · We analyzed DepMap (Project Achilles, Broad Institute) datasets (23Q2 release) reporting on genome-scale CRISPR-Cas9 knockout screens performed across >1,000 cancer cell lines 40 including 23 SCLC cell lines in total and all four POU2F3-positive cell lines (NCI-H1048, NCI-H211, NCI-H526 and COR-L311).
Transcriptome analysis reveals tumor microenvironment ... - Cell …
2023年4月10日 · Single-cell RNA sequencing (scRNA-seq) has revealed tumor-intrinsic transcriptional programs reflecting neural progenitor (NPC) and oligodendrocyte progenitor (OPC) cell-like states. 13 Because expression data can quantify higher-level processes and identify epigenetic changes, investigation of tumor evolution on the transcriptional level may ...
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and
2023年6月15日 · We further discovered co-regulation of co-stimulatory (CD58) and co-inhibitory (PD-L1) cancer cell signals by the stabilizing molecule CMTM6. Altogether, this study emphasizes the importance of cancer cell-intrinsic expression of CD58 for cancer immunity.
Conserved pan-cancer microenvironment subtypes predict ... - Cell …
Here, we developed an accessible transcriptomic analysis platform for TME classification to identify functional gene sets defined by cellular populations, signaling signatures, TME processes, and cancer cell properties that ensure comprehensive characterization of both …