IL27RA Gene - GeneCards | I27RA Protein | I27RA Antibody
2024年12月9日 · IL27RA (Interleukin 27 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL27RA include Epilepsy and Autism Spectrum Disorder. Among its related pathways are IL27-mediated signaling events and Interleukin-12 family signaling.
Interleukin 27 receptor, alpha subunit - Wikipedia
Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene. [5] In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12.
Role of IL-27 in Epstein–Barr virus infection revealed by IL-27RA ...
2024年3月20日 · Here we report biallelic loss-of-function variants in IL27RA that underlie an acute and severe primary EBV infection with a nevertheless favourable outcome requiring a minimal treatment.
清华大学药学院王建伟团队在《BLOOD》杂志报导了慢性炎症信号 …
与野生型小鼠相比，IL27Ra-/-小鼠HSC在LPS刺激下扩增能力更弱，表明IL27Ra可以作为传感器（sensor）分子响应炎症信号，促使HSC大量扩增。 至此，研究者阐明了衰老相关的慢性炎症通过TNFα→ERK→ETS1→IL27Ra通路损伤HSC的分子机制。
IL27RA interleukin 27 receptor subunit alpha [ (human)]
Cytokine receptor IL27RA is an NF-kappaB-responsive gene involved in CD38 upregulation in multiple myeloma. Structural insights into the assembly and activation of the IL-27 signaling complex. IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma.
IL-27 disturbs lipid metabolism and restrains mitochondrial
2024年7月9日 · Il27ra deficient splenic γδ T cells produced higher levels of IL-17 and were more pathogenic when transferred into Tcrd-/-mice. Intracutaneous injection of IL-27 inhibited the production of...
IL-27R signaling controls myeloid cells accumulation and
2017年5月23日 · IL-27R was shown to suppress T cells activation in atherosclerosis, however it’s possible role in myeloid cell accumulation and activation is not understood. Here we demonstrate that Apoe −/−...
IL27RA interleukin 27 receptor subunit alpha [ Homo sapiens …
2023年11月23日 · These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
Interleukin-27: Balancing Protective and Pathological Immunity
2012年12月14日 · Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the Epstein-Barr virus-induced gene 3 (EBi3) and IL-27p28, which engages a receptor composed of gp130 and the IL-27Rα that activates Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and mitogen activated protein kinase (MAPK) signaling (see Figure 1; Kastele...
Interleukin-27 signaling serves as an immunological checkpoint for ...
2022年8月8日 · We found that IL-27 receptor (IL-27R) signaling promotes HCC development in vivo. High IL-27EBI3 cytokine or IL-27RA expression correlated with poor prognosis for patients with HCC. Loss of IL-27R suppressed HCC in vivo in two different models of hepatocarcinogenesis.